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May 26, 2016

Biomechanical Effects of Femtosecond and Microkeratome-based Flap Creation: Prospective Contralateral Examination of Two Patients

Journal of Refractive Surgery
Understanding and minimizing the biomechanical effects of LASIK surgery can optimize the predictability of outcomes. The biomechanical shifts caused with flap creation appear to be more controllable with a uniform thickness flap that can be created using a femtosecond laser.
May 03, 2016

Surface Wave Elastometry of the Cornea in Porcine and Human Donor Eyes

Journal of Refractive Surgery
The cornea functions as a mechanical barrier to injury and a transparent scaffold for the eye's primary refracting surface, the tear film. The material properties of the cornea are integral to each of these functions and impact its response to disease and surgery. To better ascertain the relevance of these properties in clinical ophthalmology, techniques that are capable of characterizing material behavior in a nondestructive fashion are needed.
April 21, 2016

Anterior Segment Imaging: New Milestones, New Challenges

Journal of Cataract and Refractive Surgery
Imaging the anterior segment has improved dramatically in recent years. The benefits of these refinements are clear and have led to their broad adoption in clinical practice. But what is the cost of complexity? The idiosyncrasies of each refinement influence the output, and as layers are added, we are less likely to appreciate the ‘‘wrinkles’’ that each contributes.
April 15, 2016

Biomechanics and Wound Healing in the Cornea.

Experimental Eye Research
The biomechanical and wound healing properties of the cornea undermine the predictability and stability of refractive surgery and contribute to discrepancies between attempted and achieved visual outcomes after LASIK, surface ablation and other keratorefractive procedures. Surgical and disease models that integrate corneal geometric data, substructural anatomy, elastic and viscoelastic material properties and wound healing behavior have the potential to improve clinical outcomes and minimize complications but depend on the identification of preoperative predictors of biomechanical and wound healing responses in individual patients.
April 01, 2016

Biomechanical Modeling of Corneal Ectasia

Journal of Refractive Surgery
Check out one of our groups orignal papers. It's an excellent primer on the biomechanical properties of the cornea and how their sub-optimal manifestations can lead to corneal ectasia.
March 21, 2016

OptoQuest Sponsors Booth (#2554) at ASCRS 2016 in New Orleans

OptoQuest will be at the American Society of Cataract & Refractive Surgery annual meeting in New Orleans from May 6-10 at booth #2554. Join us to get a preview of a revolutionary approach to planning and optimizing refractive and corneal surgery!
November 17, 2015

Corneal Biomechanics and Refractive Surgery

EyeNet Blog Post
Refractive surgeons can now perform a highly precise workup prior to surgery—and thanks to developments such as wavefront technology, they can deliver highly precise treatment. But how can the preoperative testing and treatment be better linked?
September 08, 2015

Biomechanics of the Crosslinked Cornea

Advances in Corneal Biomechanics
Watch Dr. Dupps explain newer methods of assessing both pre and post-crosslinked corneas as well as a sneak peak into what we have in development. Current diagnostic technologies include air puff devices like the Ocular Response Analyzer and Corvis ST. Emerging techniques include OCT based elastography and Brillouin Microscopy.
May 04, 2015

A fiber-reinforced porohyperelastic swelling model for mechanical behavior of cornea: Application to prediction of keratoconus initiation

ARVO 2015 Presentation
See the abstract of our new findings on modeling key properties of keratoconus development. Full paper still to come!
May 04, 2015

Biomechanical Comparison Of Contralateral Flap-Based And No-Flap Femtosecond Lenticule Extraction Procedures Using Inverse Finite Element Analysis

ARVO 2015 Poster
Missed our poster's at ARVO? Check it out now.
December 15, 2014

BAC-EDTA transepithelial riboflavin-UVA crosslinking has greater biomechanical stiffening effect than standard epithelium-off in rabbit corneas

Experimental Eye Research
Abstract:  Studies suggest that standard corneal collagen crosslinking (CXL) is a safe and effective treatment to stiffen the cornea for keratoconus and other ectatic corneal disorders. The purpose of the present study was to compare the biomechanical effects of transepithelial benzalkonium chloride-EDTA (BAC-EDTA) riboflavin-UVA crosslinking to standard epithelium-off riboflavin-UVA crosslinking in a rabbit model.
June 18, 2014

Toric Topographically Customized Transepithelial, Pulsed, Very High-Fluence, Higher Energy and Higher Riboflavin Concentration Collagen Cross-Linking in Keratoconus

Case Reports in Ophthalmology
PURPOSE: To report a novel application of toric topographically customized transepithelial collagen cross-linking (CXL) aiming to achieve refractive astigmatic changes in a keratoconic cornea.
June 01, 2014

Comparison of biomechanical effects of small-incision lenticule extraction and laser in situ keratomileusis: Finite-element analysis.

Journal of Cataract & Refractive Surgery
PURPOSE: To theoretically compare the corneal stress distribution of laser in situ keratomileusis (LASIK) with the stress distribution of small-incision lenticule extraction.
June 01, 2014

Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography.

Journal of Cataract and Refractive Surgery
PURPOSE: To noninvasively evaluate the effects of corneal hydration and collagen crosslinking (CXL) on the mechanical behavior of the cornea.
June 01, 2014

Patterned corneal collagen crosslinking for astigmatism: Computational modeling study.

Journal of Cataract and Refractive Surgery
PURPOSE: To test the hypothesis that spatially selective corneal stromal stiffening can alter corneal astigmatism and assess the effects of treatment orientation, pattern, and material model complexity in computational models using patient-specific geometries.
June 01, 2014

Biomechanics of corneal ectasia and biomechanical treatments

Journal of Cataract and Refractive Surgery
It is proposed that the primary abnormality in keratoconus and post-refractive surgery ectasia is in the biomechanical properties.
May 15, 2014

Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects.

Current Eye Research
Biomechanics is the study of the relationship between forces and function in living organisms and is thought to play a critical role in a significant number of ophthalmic disorders.
April 27, 2014

Biomechanical Modeling & Refractive Cross-Linking

Avedro Booth Lecture Series
"Modeling Results of Crosslinking-­‐Driven Refractive Treatment" - a lecture Dr. Dupps presented at the 2014 ASCRS Symposium & Congress
March 05, 2014

Bioscience prominent in latest Third Frontier funding round

Bioscience prominent in latest Third Frontier funding round 

Earlier this week the Ohio Third Frontier Commission recommended more than $21 million in funding via the Innovation Platform Program. Bioscience-related collaborations accounted for more than $11 million of the investment.
February 10, 2014

What tool or method is best for diagnosing keratoconus?

Ocular Surgery News
What tool or method is best for diagnosing keratoconus?

I think it is important to begin by stipulating that no currently available tool for diagnosing keratoconus provides a complete view of the disease state.
November 05, 2013

Biological and Biomechanical Responses to Traditional Epithelium-Off and Transepithelial Riboflavin-UVA CXL Techniques in Rabbits

Journal of Refractive Surgery
PURPOSE: To compare the biological effects of ribofl avinultraviolet A (UVA) corneal cross-linking (CXL) performed with a traditional epithelium-off method to several transepithelial methods in a rabbit model. Preliminary experiments on biomechanical rigidity were also performed.
July 26, 2012

OptoQuest and partners at Cleveland Clinic receive a $3 million Ohio Third Frontier Innovation Platform commercialization award. Top ranked proposal by the National Academies

The Business Journal
OptoQuest and partners at Cleveland Clinic receive a $3 million Ohio Third Frontier Innovation Platform commercialization award. Top ranked proposal by the National Academies 

Cleveland Clinic was awarded approximately $3 million for its Ophthalmic Imaging Center project in collaboration with OptoQuest Corp., ImageIQ, Avedro, Bioptigen, and Peregrine Surgical.
November 25, 2011

Patient-specific computational modeling of keratoconus progression and differential responses to collagen cross-linking


To model keratoconus (KC) progression and investigate the differential responses of central and eccentric cones to standard and alternative collagen cross-linking (CXL) patterns.

January 15, 2011

Method for optical coherence elastography of the cornea
The material properties of the cornea are important determinants of corneal shape and refractive power.
January 13, 2011

Patient-specific modeling of corneal refractive surgery outcomes and inverse estimation of elastic property changes
The purpose of this study was to develop a 3D patient-specific finite element model (FEM) of the cornea and sclera to compare predicted and in vivo refractive outcomes and to estimate the corneal elastic property changes associated with each procedure.
October 25, 2009

Effects of altered corneal stiffness on native and postoperative LASIK corneal biomechanical behavior: A whole-eye finite element analysis

This modeling study demonstrated that differences in the corneoscleral stiffness relationship may be a source of individual variation in refractive surgery outcomes.